The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B

The ARF tumor suppressor is part of the CDKN2A locus and is mutated or undetectable in numerous cancers. The best-characterized role for ARF is in stabilizing p53 in response to cellular stress. However, ARF has tumor suppressive functions outside this pathway that have not been fully defined. Prima...

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Detalles Bibliográficos
Autores principales: Britigan, Eric M.C., Wan, Jun, Zasadil, Lauren M., Ryan, Sean D., Weaver, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161511/
https://www.ncbi.nlm.nih.gov/pubmed/25057018
http://dx.doi.org/10.1091/mbc.E14-05-0966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161511/
https://www.ncbi.nlm.nih.gov/pubmed/25057018
http://dx.doi.org/10.1091/mbc.E14-05-0966

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