A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro

BACKGROUND: Elevated glucose concentrations lead to increased insulin secretion and suppression of glucagon secretion. In fact, insulin is a physiological inhibitor of glucagon secretion. Type 2 diabetes mellitus (T2DM) patients have defects in insulin secretion. In addition to this, lack of suppres...

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Detalles Bibliográficos
Autores principales: Verma, Mahesh Kumar, Biswas, Sanghamitra, Chandravanshi, Bhawna, Neelima, Korrapati, Oommen, Anup M, Jagannath, Madanahalli R, Somesh, Baggavalli P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161845/
https://www.ncbi.nlm.nih.gov/pubmed/25186493
http://dx.doi.org/10.1186/1756-0500-7-595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161845/
https://www.ncbi.nlm.nih.gov/pubmed/25186493
http://dx.doi.org/10.1186/1756-0500-7-595

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