dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages

BACKGROUND: SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages. Recently, viral protein X (Vpx) of HIV-2/SIVsm was shown to target SAMHD1 for proteosomal degradation and led to elevation of dNTP levels, which in turn accelerated proviral DNA synthesis of len...

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Detalles Bibliográficos
Autores principales: Hollenbaugh, Joseph A, Tao, Sijia, Lenzi, Gina M, Ryu, Sulryung, Kim, Dong-Hyun, Diaz-Griffero, Felipe, Schinazi, Raymond F, Kim, Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161909/
https://www.ncbi.nlm.nih.gov/pubmed/25158827
http://dx.doi.org/10.1186/s12977-014-0063-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161909/
https://www.ncbi.nlm.nih.gov/pubmed/25158827
http://dx.doi.org/10.1186/s12977-014-0063-2

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