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Streptomycin potency is dependent on MscL channel expression

The antibiotic streptomycin is widely used in the treatment of microbial infections. The primary mechanism of action is inhibition of translation by binding to the ribosome, but how it enters the bacterial cell is unclear. Early in the study of this antibiotic, a mysterious streptomycin-induced K(+)...

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Detalles Bibliográficos
Autores principales: Iscla, Irene, Wray, Robin, Wei, Shuguang, Posner, Bruce, Blount, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161981/
https://www.ncbi.nlm.nih.gov/pubmed/25205267
http://dx.doi.org/10.1038/ncomms5891