Profiling the Mitochondrial Proteome of Leber’s Hereditary Optic Neuropathy (LHON) in Thailand: Down-Regulation of Bioenergetics and Mitochondrial Protein Quality Control Pathways in Fibroblasts with the 11778G>A Mutation

Leber’s Hereditary Optic Neuropathy (LHON) is one of the commonest mitochondrial diseases. It causes total blindness, and predominantly affects young males. For the disease to develop, it is necessary for an individual to carry one of the primary mtDNA mutations 11778G>A, 14484T>C or 3460G>...

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Detalles Bibliográficos
Autores principales: Tun, Aung Win, Chaiyarit, Sakdithep, Kaewsutthi, Supannee, Katanyoo, Wanphen, Chuenkongkaew, Wanicha, Kuwano, Masayoshi, Tomonaga, Takeshi, Peerapittayamongkol, Chayanon, Thongboonkerd, Visith, Lertrit, Patcharee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162555/
https://www.ncbi.nlm.nih.gov/pubmed/25215595
http://dx.doi.org/10.1371/journal.pone.0106779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162555/
https://www.ncbi.nlm.nih.gov/pubmed/25215595
http://dx.doi.org/10.1371/journal.pone.0106779

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