PP4 Is Essential for Germinal Center Formation and Class Switch Recombination in Mice

PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig) VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4 in mature B cells, we ablated the catalytic subunit of murine PP4 in vivo utilizing the CD23 promoter and cre-loxP recombination and generat...

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Detalles Bibliográficos
Autores principales: Chen, Ming-Yu, Chen, Ya-Ping, Wu, Ming-Sian, Yu, Guanni-Yi, Lin, Wen-Jye, Tan, Tse-Hua, Su, Yu-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162579/
https://www.ncbi.nlm.nih.gov/pubmed/25215539
http://dx.doi.org/10.1371/journal.pone.0107505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162579/
https://www.ncbi.nlm.nih.gov/pubmed/25215539
http://dx.doi.org/10.1371/journal.pone.0107505

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