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PP4 Is Essential for Germinal Center Formation and Class Switch Recombination in Mice

PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig) VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4 in mature B cells, we ablated the catalytic subunit of murine PP4 in vivo utilizing the CD23 promoter and cre-loxP recombination and generat...

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Detalles Bibliográficos
Autores principales:	Chen, Ming-Yu, Chen, Ya-Ping, Wu, Ming-Sian, Yu, Guanni-Yi, Lin, Wen-Jye, Tan, Tse-Hua, Su, Yu-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162579/ https://www.ncbi.nlm.nih.gov/pubmed/25215539 http://dx.doi.org/10.1371/journal.pone.0107505

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