Energetic Changes Caused by Antigenic Module Insertion in a Virus-Like Particle Revealed by Experiment and Molecular Dynamics Simulations

The success of recombinant virus-like particles (VLPs) for human papillomavirus and hepatitis B demonstrates the potential of VLPs as safe and efficacious vaccines. With new modular designs emerging, the effects of antigen module insertion on the self-assembly and structural integrity of VLPs should...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J., Sun, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162605/
https://www.ncbi.nlm.nih.gov/pubmed/25215874
http://dx.doi.org/10.1371/journal.pone.0107313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162605/
https://www.ncbi.nlm.nih.gov/pubmed/25215874
http://dx.doi.org/10.1371/journal.pone.0107313

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