Meta-analysis of randomized phase II trials to inform subsequent phase III decisions

BACKGROUND: If multiple Phase II randomized trials exist then meta-analysis is favorable to increase statistical power and summarize the existing evidence about an intervention's effect in order to help inform Phase III decisions. We consider some statistical issues for meta-analysis of Phase I...

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Detalles Bibliográficos
Autores principales: Burke, Danielle L, Billingham, Lucinda J, Girling, Alan J, Riley, Richard D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162965/
https://www.ncbi.nlm.nih.gov/pubmed/25187348
http://dx.doi.org/10.1186/1745-6215-15-346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162965/
https://www.ncbi.nlm.nih.gov/pubmed/25187348
http://dx.doi.org/10.1186/1745-6215-15-346

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