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Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling

The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical process for development. Several negative feedback mechanisms are in place, including the Shh-induced upregulation of Hedgehog interacting protein (Hhip). Hhip sequesters Shh, leading to a non-cell autonomous inhibition of t...

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Detalles Bibliográficos
Autores principales: Kwong, Lina, Bijlsma, Maarten F., Roelink, Henk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163939/
https://www.ncbi.nlm.nih.gov/pubmed/25215859
http://dx.doi.org/10.1038/ncomms5849