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Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling
The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical process for development. Several negative feedback mechanisms are in place, including the Shh-induced upregulation of Hedgehog interacting protein (Hhip). Hhip sequesters Shh, leading to a non-cell autonomous inhibition of t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163939/ https://www.ncbi.nlm.nih.gov/pubmed/25215859 http://dx.doi.org/10.1038/ncomms5849 |