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MET and PI3K/mTOR as a Potential Combinatorial Therapeutic Target in Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive disease with a poor prognosis. Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. Here we determined the combinatorial therapeutic efficacy of a new generation small...
Autores principales: | Kanteti, Rajani, Dhanasingh, Immanuel, Kawada, Ichiro, Lennon, Frances E., Arif, Qudsia, Bueno, Raphael, Hasina, Rifat, Husain, Aliya N., Vigneswaran, Wickii, Seiwert, Tanguy, Kindler, Hedy L., Salgia, Ravi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164360/ https://www.ncbi.nlm.nih.gov/pubmed/25221930 http://dx.doi.org/10.1371/journal.pone.0105919 |
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