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Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development
The concept of 'equipoise', or the 'uncertainty principle', has been represented as a central ethical principle, and holds that a subject may be enrolled in a randomized controlled trial (RCT) only if there is true uncertainty about which of the trial arms is most likely to benef...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416446/ https://www.ncbi.nlm.nih.gov/pubmed/15142271 http://dx.doi.org/10.1186/ar1170 |