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Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells

INTRODUCTION: The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. In the present study, we examined the potential benefits of sustained overexpr...

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Detalles Bibliográficos
Autores principales: Frisch, Janina, Venkatesan, Jagadeesh Kumar, Rey-Rico, Ana, Schmitt, Gertrud, Madry, Henning, Cucchiarini, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164762/
https://www.ncbi.nlm.nih.gov/pubmed/25163769
http://dx.doi.org/10.1186/scrt491