4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

eIF4E-binding proteins (4E-BPs) are a widespread class of translational regulators that share a canonical (C) eIF4E-binding motif (4E-BM) with eIF4G. Consequently, 4E-BPs compete with eIF4G for binding to the dorsal surface on eIF4E to inhibit translation initiation. Some 4E-BPs contain non-canonica...

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Detalles Bibliográficos
Autores principales: Igreja, Cátia, Peter, Daniel, Weiler, Catrin, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164784/
https://www.ncbi.nlm.nih.gov/pubmed/25179781
http://dx.doi.org/10.1038/ncomms5790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164784/
https://www.ncbi.nlm.nih.gov/pubmed/25179781
http://dx.doi.org/10.1038/ncomms5790

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