Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways

Decline in the gene expression of senescence repressor Bmi1, and telomerase, together with telomere shortening, underlay senescence of stem cells cultured for multiple passages. Here, we investigated whether the impairment of senescence preventing mechanisms can be efficiently counteracted by exposu...

Descripción completa

Detalles Bibliográficos
Autores principales: Rinaldi, S., Maioli, M., Pigliaru, G., Castagna, A., Santaniello, S., Basoli, V., Fontani, V., Ventura, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165271/
https://www.ncbi.nlm.nih.gov/pubmed/25224681
http://dx.doi.org/10.1038/srep06373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165271/
https://www.ncbi.nlm.nih.gov/pubmed/25224681
http://dx.doi.org/10.1038/srep06373

Ejemplares similares