Substrate Positioning by Gln(239) Stimulates Turnover in Factor Inhibiting HIF, an αKG-Dependent Hydroxylase

[Image: see text] Nonheme Fe(II)/αKG-dependent oxygenases catalyze diverse reactions, typically inserting an O atom from O(2) into a C–H bond. Although the key to their catalytic cycle is the fact that binding and positioning of primary substrate precede O(2) activation, the means by which substrate...

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Detalles Bibliográficos
Autores principales: Hangasky, John A., Ivison, Geoffrey T., Knapp, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165446/
https://www.ncbi.nlm.nih.gov/pubmed/25119663
http://dx.doi.org/10.1021/bi500703s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165446/
https://www.ncbi.nlm.nih.gov/pubmed/25119663
http://dx.doi.org/10.1021/bi500703s

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