Discovery of a Chemical Modification by Citric Acid in a Recombinant Monoclonal Antibody

[Image: see text] Recombinant therapeutic monoclonal antibodies exhibit a high degree of heterogeneity that can arise from various post-translational modifications. The formulation for a protein product is to maintain a specific pH and to minimize further modifications. Generally Recognized as Safe...

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Detalles Bibliográficos
Autores principales: Chumsae, Chris, Zhou, Liqiang Lisa, Shen, Yang, Wohlgemuth, Jessica, Fung, Emma, Burton, Randall, Radziejewski, Czeslaw, Zhou, Zhaohui Sunny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165448/
https://www.ncbi.nlm.nih.gov/pubmed/25136741
http://dx.doi.org/10.1021/ac502179m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165448/
https://www.ncbi.nlm.nih.gov/pubmed/25136741
http://dx.doi.org/10.1021/ac502179m

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