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Discovery of a Chemical Modification by Citric Acid in a Recombinant Monoclonal Antibody
[Image: see text] Recombinant therapeutic monoclonal antibodies exhibit a high degree of heterogeneity that can arise from various post-translational modifications. The formulation for a protein product is to maintain a specific pH and to minimize further modifications. Generally Recognized as Safe...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165448/ https://www.ncbi.nlm.nih.gov/pubmed/25136741 http://dx.doi.org/10.1021/ac502179m |