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IL-18, but not IL-12, induces production of IFN-γ in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin
IFN-γ plays a central role in the defense against infections and cancer. More recently, however, IFN-γ has also been reported to have immunosuppressive effects in models of autoimmune disease, melanoma and premalignant skin disease. While IL-12 and IL-18 are critical inducers of IFN-γ during infecti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165718/ https://www.ncbi.nlm.nih.gov/pubmed/24756108 http://dx.doi.org/10.1038/jid.2014.201 |