Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration

Malignant gliomas are characterized by neurodegenerative actions leading to the destruction of surrounding brain parenchyma. The disturbance in glutamate homeostasis caused by increased expression of the glutamate transporter xCT plays a key role in glioma progression. We demonstrate that the HDAC-i...

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Detalles Bibliográficos
Autores principales: Wolf, Ines M. L., Fan, Zheng, Rauh, Manfred, Seufert, Sebastian, Hore, Nirjhar, Buchfelder, Michael, Savaskan, Nic E., Eyüpoglu, Ilker Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165982/
https://www.ncbi.nlm.nih.gov/pubmed/25228443
http://dx.doi.org/10.1038/srep06226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165982/
https://www.ncbi.nlm.nih.gov/pubmed/25228443
http://dx.doi.org/10.1038/srep06226

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