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Towards accurate characterization of clonal heterogeneity based on structural variation
BACKGROUND: Recent advances in deep digital sequencing have unveiled an unprecedented degree of clonal heterogeneity within a single tumor DNA sample. Resolving such heterogeneity depends on accurate estimation of fractions of alleles that harbor somatic mutations. Unlike substitutions or small inde...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165998/ https://www.ncbi.nlm.nih.gov/pubmed/25201439 http://dx.doi.org/10.1186/1471-2105-15-299 |