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Towards accurate characterization of clonal heterogeneity based on structural variation

BACKGROUND: Recent advances in deep digital sequencing have unveiled an unprecedented degree of clonal heterogeneity within a single tumor DNA sample. Resolving such heterogeneity depends on accurate estimation of fractions of alleles that harbor somatic mutations. Unlike substitutions or small inde...

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Detalles Bibliográficos
Autores principales:	Fan, Xian, Zhou, Wanding, Chong, Zechen, Nakhleh, Luay, Chen, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165998/ https://www.ncbi.nlm.nih.gov/pubmed/25201439 http://dx.doi.org/10.1186/1471-2105-15-299

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