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The Role of the Lys628 (192) Residue of the Complement Protease, C1s, in Interacting with Peptide and Protein Substrates

The C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components. This facilitates the formation of the classical pathway C3 convertase (C4bC2a). C1s has a Lys residue located a...

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Detalles Bibliográficos
Autores principales: Wijeyewickrema, Lakshmi Carmel, Duncan, Renee Charlene, Pike, Robert Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166353/
https://www.ncbi.nlm.nih.gov/pubmed/25278939
http://dx.doi.org/10.3389/fimmu.2014.00444