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Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis

BACKGROUND: Systemic sclerosis (SSc) is characterized by vascular alteration and fibrosis, the former probably leading to fibrosis via the ability of both endothelial cells and pericytes to differentiate toward myofibroblast. It is well known that vascular endothelial growth factor A (VEGF-A, hereaf...

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Detalles Bibliográficos
Autores principales: Cipriani, Paola, Di Benedetto, Paola, Capece, Daria, Zazzeroni, Francesca, Liakouli, Vasiliki, Ruscitti, Piero, Pantano, Ilenia, Berardicurti, Onorina, Carubbi, Francesco, Alesse, Edoardo, Giacomelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166421/
https://www.ncbi.nlm.nih.gov/pubmed/25237397
http://dx.doi.org/10.1186/1755-1536-7-13