The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

Both DNA and histone methylation are dysregulated in the myelodysplastic syndromes (MDS). Based on preliminary data we hypothesized that dysregulated interactions of KDM2B, let-7b and EZH2 signals lead to an aberrant epigenetic landscape. Gene expression in CD34+ cells from MDS marrows was analyzed...

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Detalles Bibliográficos
Autores principales: Karoopongse, Ekapun, Yeung, Cecilia, Byon, John, Ramakrishnan, Aravind, Holman, Zaneta J., Jiang, Peter Y. Z., Yu, Qiang, Deeg, H. Joachim, Marcondes, A. Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166605/
https://www.ncbi.nlm.nih.gov/pubmed/25225797
http://dx.doi.org/10.1371/journal.pone.0107817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166605/
https://www.ncbi.nlm.nih.gov/pubmed/25225797
http://dx.doi.org/10.1371/journal.pone.0107817

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