Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors

Plasmodium falciparum alanine M1-aminopeptidase (PfA-M1) is a validated target for anti-malarial drug development. Presence of significant similarity between PfA-M1 and human M1-aminopeptidases, particularly within regions of enzyme active site leads to problem of non-specificity and off-target bind...

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Detalles Bibliográficos
Autores principales: Sahi, Shakti, Rai, Sneha, Chaudhary, Meenakshi, Nain, Vikrant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2014
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166772/
https://www.ncbi.nlm.nih.gov/pubmed/25258488
http://dx.doi.org/10.6026/97320630010518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166772/
https://www.ncbi.nlm.nih.gov/pubmed/25258488
http://dx.doi.org/10.6026/97320630010518

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