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Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, a...

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Autores principales: Otto, Thomas D., Rayner, Julian C., Böhme, Ulrike, Pain, Arnab, Spottiswoode, Natasha, Sanders, Mandy, Quail, Michael, Ollomo, Benjamin, Renaud, François, Thomas, Alan W., Prugnolle, Franck, Conway, David J., Newbold, Chris, Berriman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166903/
https://www.ncbi.nlm.nih.gov/pubmed/25203297
http://dx.doi.org/10.1038/ncomms5754
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author Otto, Thomas D.
Rayner, Julian C.
Böhme, Ulrike
Pain, Arnab
Spottiswoode, Natasha
Sanders, Mandy
Quail, Michael
Ollomo, Benjamin
Renaud, François
Thomas, Alan W.
Prugnolle, Franck
Conway, David J.
Newbold, Chris
Berriman, Matthew
author_facet Otto, Thomas D.
Rayner, Julian C.
Böhme, Ulrike
Pain, Arnab
Spottiswoode, Natasha
Sanders, Mandy
Quail, Michael
Ollomo, Benjamin
Renaud, François
Thomas, Alan W.
Prugnolle, Franck
Conway, David J.
Newbold, Chris
Berriman, Matthew
author_sort Otto, Thomas D.
collection PubMed
description Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host–parasite interface may have mediated host switching.
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spelling pubmed-41669032014-09-22 Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts Otto, Thomas D. Rayner, Julian C. Böhme, Ulrike Pain, Arnab Spottiswoode, Natasha Sanders, Mandy Quail, Michael Ollomo, Benjamin Renaud, François Thomas, Alan W. Prugnolle, Franck Conway, David J. Newbold, Chris Berriman, Matthew Nat Commun Article Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host–parasite interface may have mediated host switching. Nature Pub. Group 2014-09-09 /pmc/articles/PMC4166903/ /pubmed/25203297 http://dx.doi.org/10.1038/ncomms5754 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Article
Otto, Thomas D.
Rayner, Julian C.
Böhme, Ulrike
Pain, Arnab
Spottiswoode, Natasha
Sanders, Mandy
Quail, Michael
Ollomo, Benjamin
Renaud, François
Thomas, Alan W.
Prugnolle, Franck
Conway, David J.
Newbold, Chris
Berriman, Matthew
Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title_full Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title_fullStr Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title_full_unstemmed Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title_short Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
title_sort genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166903/
https://www.ncbi.nlm.nih.gov/pubmed/25203297
http://dx.doi.org/10.1038/ncomms5754
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