Role of tRNA Orthogonality in an Expanded Genetic Code

[Image: see text] We found that Methanocaldococcus jannaschii DSM2661 tyrosyl-tRNA synthetase (Mj E9RS), specifically evolved to charge its cognate tRNA with the unnatural amino acid p-acetylphenylalanine (pAcF) in E. coli, misaminoacylates the endogenous E. coli prolyl-tRNAs with pAcF at a low leve...

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Detalles Bibliográficos
Autores principales: Javahishvili, Tsotne, Manibusan, Anthony, Srinagesh, Shaila, Lee, Darin, Ensari, Semsi, Shimazu, Mark, Schultz, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167058/
https://www.ncbi.nlm.nih.gov/pubmed/24443971
http://dx.doi.org/10.1021/cb4005172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167058/
https://www.ncbi.nlm.nih.gov/pubmed/24443971
http://dx.doi.org/10.1021/cb4005172

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