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Direct Evidence of Catalytic Heterogeneity in Lactate Dehydrogenase by Temperature Jump Infrared Spectroscopy
[Image: see text] Protein conformational heterogeneity and dynamics are known to play an important role in enzyme catalysis, but their influence has been difficult to observe directly. We have studied the effects of heterogeneity in the catalytic reaction of pig heart lactate dehydrogenase using iso...
Autores principales: | Reddish, Michael J., Peng, Huo-Lei, Deng, Hua, Panwar, Kunal S., Callender, Robert, Dyer, R. Brian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167064/ https://www.ncbi.nlm.nih.gov/pubmed/25149276 http://dx.doi.org/10.1021/jp5050546 |
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