Enzymatic mono-pegylation of glucagon-like peptide 1 towards long lasting treatment of type 2 diabetes

Human glucagon-like peptide-1 (GLP-1) is a physiological gastrointestinal peptide with glucose-dependent insulinotropic effects which is therefore considered an interesting antidiabetic agent. However, after in vivo administration, exogenous GLP-1 does not exert its physiological action due to the c...

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Detalles Bibliográficos
Autores principales: Selis, Fabio, Schrepfer, Rodolfo, Sanna, Riccardo, Scaramuzza, Silvia, Tonon, Giancarlo, Dedoni, Simona, Onali, Pierluigi, Orsini, Gaetano, Genovese, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167179/
https://www.ncbi.nlm.nih.gov/pubmed/25755995
http://dx.doi.org/10.1016/j.rinphs.2012.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167179/
https://www.ncbi.nlm.nih.gov/pubmed/25755995
http://dx.doi.org/10.1016/j.rinphs.2012.09.001

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