Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

BACKGROUND: Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 and PTEN genes, respectively. Estimation of cancer risk is crucial in order...

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Detalles Bibliográficos
Autores principales: Forte, Giovanna, Grossi, Valentina, Celestini, Valentina, Lucisano, Giuseppe, Scardapane, Marco, Varvara, Dora, Patruno, Margherita, Bagnulo, Rosanna, Loconte, Daria, Giunti, Laura, Petracca, Antonio, Giglio, Sabrina, Genuardi, Maurizio, Pellegrini, Fabio, Resta, Nicoletta, Simone, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167262/
https://www.ncbi.nlm.nih.gov/pubmed/25208626
http://dx.doi.org/10.1186/1471-2407-14-661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167262/
https://www.ncbi.nlm.nih.gov/pubmed/25208626
http://dx.doi.org/10.1186/1471-2407-14-661

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