Long distance effect on ligand-gated ion channels extracellular domain may affect interactions with the intracellular machinery

Modulation of receptor trafficking is critical for controlling neurotransmission. A γ2(R43Q) point mutation on GABA(A) receptor subunit is linked to epilepsy in human. We recently analyzed the effect of this amino-acid substitution on GABA(A) receptor trafficking and showed that this mutation as wel...

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Detalles Bibliográficos
Autores principales: Garret, Maurice, Boué-Grabot, Eric, Taly, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167410/
https://www.ncbi.nlm.nih.gov/pubmed/25254078
http://dx.doi.org/10.4161/cib.27984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167410/
https://www.ncbi.nlm.nih.gov/pubmed/25254078
http://dx.doi.org/10.4161/cib.27984

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