Gene Expression and Pathway Analysis of Effects of the CMAH Deactivation on Mouse Lung, Kidney and Heart

BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene during evolution. CMAH is one of severa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwon, Deug-Nam, Chang, Byung-Soo, Kim, Jin-Hoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167996/
https://www.ncbi.nlm.nih.gov/pubmed/25229777
http://dx.doi.org/10.1371/journal.pone.0107559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167996/
https://www.ncbi.nlm.nih.gov/pubmed/25229777
http://dx.doi.org/10.1371/journal.pone.0107559

Ejemplares similares