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Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133(+) cells in triple-negative breast cancer
BACKGROUND: Hypoxia induced by antiangiogenic agents is linked to the generation of cancer stem cells (CSCs) and treatment failure through unknown mechanisms. The generation of endothelial cell-independent microcirculation in malignant tumors is defined as tumor cell vasculogenic mimicry (VM). In th...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168051/ https://www.ncbi.nlm.nih.gov/pubmed/25200065 http://dx.doi.org/10.1186/1476-4598-13-207 |