siRNAs targeted to Smad4 prevent renal fibrosis in vivo

Renal fibrosis is the final common pathway leading to decreased renal function. No therapy has been established to prevent it. In order to establish a therapeutic approach and target molecule for renal fibrosis, we investigated the effects of Smad4 knockdown by siRNAs on renal fibrosis in vivo. Rena...

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Detalles Bibliográficos
Autores principales: Morishita, Yoshiyuki, Yoshizawa, Hiromichi, Watanabe, Minami, Ishibashi, Kenichi, Muto, Shigeaki, Kusano, Eiji, Nagata, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168270/
https://www.ncbi.nlm.nih.gov/pubmed/25236771
http://dx.doi.org/10.1038/srep06424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168270/
https://www.ncbi.nlm.nih.gov/pubmed/25236771
http://dx.doi.org/10.1038/srep06424

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