Synthesis of Complex Hexacyclic Compounds via a Tandem Rh(II)-Catalyzed Double-Cyclopropanation/Cope Rearrangement/Diels–Alder Reaction

[Image: see text] Treatment of (E)-1-(methoxymethylene)-1,2,3,4-tetrahydronaphthalene with styryl diazoacetates in the presence of catalytic amounts of the dirhodium complex Rh(2)(S-DOSP)(4) provides a highly enantioenriched hexacyclic product with 10 new stereogenic centers. The transformation proc...

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Detalles Bibliográficos
Autores principales: Spangler, Jillian E., Lian, Yajing, Raikar, Sandeep N., Davies, Huw M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168775/
https://www.ncbi.nlm.nih.gov/pubmed/25208337
http://dx.doi.org/10.1021/ol502257d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168775/
https://www.ncbi.nlm.nih.gov/pubmed/25208337
http://dx.doi.org/10.1021/ol502257d

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