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Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)
[Image: see text] The hydrocarbon-stapled peptide E1(S) allosterically inhibits the kinase activity of the epidermal growth factor receptor (EGFR) by blocking a distant but essential protein–protein interaction: a coiled coil formed from the juxtamembrane segment (JM) of each member of the dimeric p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168776/ https://www.ncbi.nlm.nih.gov/pubmed/25207804 http://dx.doi.org/10.1021/ol502426b |