Cargando…

Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)

[Image: see text] The hydrocarbon-stapled peptide E1(S) allosterically inhibits the kinase activity of the epidermal growth factor receptor (EGFR) by blocking a distant but essential protein–protein interaction: a coiled coil formed from the juxtamembrane segment (JM) of each member of the dimeric p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinclair, Julie K.-L., Schepartz, Alanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168776/ https://www.ncbi.nlm.nih.gov/pubmed/25207804 http://dx.doi.org/10.1021/ol502426b

Ejemplares similares

Inhibiting Epidermal Growth Factor Receptor at a Distance
por: Sinclair, Julie K.-L., et al.
Publicado: (2014)

A Potential Peptide Therapeutic Derived from the Juxtamembrane Domain of the Epidermal Growth Factor Receptor
por: Boran, Aislyn D. W., et al.
Publicado: (2012)

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence
por: He, Lijuan, et al.
Publicado: (2012)

Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
por: Islam, Md Shafiqul, et al.
Publicado: (2022)

Peptides derived from cadherin juxtamembrane region inhibit platelet function
por: Golla, Kalyan, et al.
Publicado: (2018)

RNA sectors and allosteric function within the ribosome
por: Walker, Allison S., et al.
Publicado: (2020)

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements
por: Plaza-Menacho, Iván, et al.
Publicado: (2016)

Rationally designed stapled peptides allosterically inhibit PTBP1–RNA-binding
por: Schmeing, Stefan, et al.
Publicado: (2023)

Cadherin juxtamembrane region derived peptides inhibit TGFβ1 induced gene expression
por: Stavropoulos, Ilias, et al.
Publicado: (2014)

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
por: de Araujo, Aline D., et al.
Publicado: (2022)

Interactions of AsCy3 with Cysteine-Rich Peptides
por: Alexander, Seth C., et al.
Publicado: (2014)

The synaptotagmin juxtamembrane domain is involved in neuroexocytosis
por: Caccin, Paola, et al.
Publicado: (2015)

In Vitro Selection of Macrocyclic α/β(3)-Peptides against Human EGFR
por: Wakabayashi, Risa, et al.
Publicado: (2022)

Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis
por: Xiao, Qiang, et al.
Publicado: (2020)

Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication
por: Qiu, Yuran, et al.
Publicado: (2021)

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition
por: Stefan, Erich, et al.
Publicado: (2021)

Peptide Stapling Applied to Antimicrobial Peptides
por: Lourenço, Ana Laura Pereira, et al.
Publicado: (2023)

Interactions of the EGFR juxtamembrane domain with PIP(2)-containing lipid bilayers: Insights from multiscale molecular dynamics simulations()
por: Abd Halim, Khairul Bariyyah, et al.
Publicado: (2015)

4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment
por: Xue, Fumin, et al.
Publicado: (2019)

Hydrocarbon Stapled Antimicrobial Peptides
por: Migoń, Dorian, et al.
Publicado: (2018)

Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle
por: Miller, Jonathan P., et al.
Publicado: (2014)

Allosteric regulation of the epidermal growth factor receptor kinase
Publicado: (1986)

Correction to “Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle”
por: Miller, Jonathan P., et al.
Publicado: (2015)

Development of an Epidermal Growth Factor Derivative with EGFR Blocking Activity
por: Panosa, Clara, et al.
Publicado: (2013)

Transmembrane and Juxtamembrane Structure of αL Integrin in Bicelles
por: Surya, Wahyu, et al.
Publicado: (2013)

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
por: Wang, Xin, et al.
Publicado: (2014)

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery
por: Ali, Ameena M., et al.
Publicado: (2019)

Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer
por: Maisel, Sabrina A., et al.
Publicado: (2019)

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE
por: Rathore, Shailendra S., et al.
Publicado: (2019)

Characterizing interaction between the juxtamembrane region of the single transmembrane protein and membrane using chemically synthesized peptides
por: Sato, Takeshi, et al.
Publicado: (2023)

Biosynthetic Strategies for Macrocyclic Peptides
por: Wang, Wei, et al.
Publicado: (2021)

RNA-Binding Macrocyclic Peptides
por: Pal, Sunit, et al.
Publicado: (2022)

AXL/epidermal growth factor receptor (EGFR) complexes in breast cancer - culprits for resistance to EGFR inhibitors?
por: Heideman, Marinus R, et al.
Publicado: (2013)

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
por: Mitra, Shreya, et al.
Publicado: (2017)

A Role for the Juxtamembrane Cytoplasm in the Molecular Dynamics of Focal Adhesions
por: Wolfenson, Haguy, et al.
Publicado: (2009)

The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors
por: Kornilov, F. D., et al.
Publicado: (2023)

Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions
por: Nag, Arundhati, et al.
Publicado: (2023)

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
por: Beyett, Tyler S., et al.
Publicado: (2022)

Macrocyclization strategies for cyclic peptides and peptidomimetics
por: Bechtler, Clément, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3u7a6hcsd3parc7gdqfcej5q5o