Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

[Image: see text] Umpolung Amide Synthesis (UmAS) provides direct access to amides from an α-bromo nitroalkane and an amine. Based on its mechanistic bifurcation after convergent C–N bond formation, depending on the absence or presence of oxygen, UmAS using substoichiometric N-iodosuccinimide (NIS)...

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Detalles Bibliográficos
Autores principales: Schwieter, Kenneth E., Shen, Bo, Shackleford, Jessica P., Leighty, Matthew W., Johnston, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168777/
https://www.ncbi.nlm.nih.gov/pubmed/25198239
http://dx.doi.org/10.1021/ol502089v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168777/
https://www.ncbi.nlm.nih.gov/pubmed/25198239
http://dx.doi.org/10.1021/ol502089v

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