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Silyl Enol Ether Prins Cyclization: Diastereoselective Formation of Substituted Tetrahydropyran-4-ones

[Image: see text] A diastereoselective synthesis of cis-2,6-disubstituted tetrahydropyran-4-ones was developed. The key step of this methodology, a silyl enol ether Prins cyclization, was promoted by a condensation reaction between a hydroxy silyl enol ether and an aldehyde to afford substituted tet...

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Detalles Bibliográficos
Autores principales:	Tay, Gidget C., Huang, Chloe Y., Rychnovsky, Scott D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168786/ https://www.ncbi.nlm.nih.gov/pubmed/25200563 http://dx.doi.org/10.1021/jo501580p

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