Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders

[Image: see text] Cornelia de Lange Syndrome (CdLS) is a multiple congenital anomaly disorder resulting from mutations in genes that encode the core components of the cohesin complex, SMC1A, SMC3, and RAD21, or two of its regulatory proteins, NIPBL and HDAC8. HDAC8 is the human SMC3 lysine deacetyla...

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Detalles Bibliográficos
Autores principales: Decroos, Christophe, Bowman, Christine M., Moser, Joe-Ann S., Christianson, Karen E., Deardorff, Matthew A., Christianson, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168803/
https://www.ncbi.nlm.nih.gov/pubmed/25075551
http://dx.doi.org/10.1021/cb5003762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168803/
https://www.ncbi.nlm.nih.gov/pubmed/25075551
http://dx.doi.org/10.1021/cb5003762

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