P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands

Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R(2)-directed Pd-catalyzed C–H activation; the functionalized products are produced with good enan...

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Detalles Bibliográficos
Autores principales: Hu, Rong-Bin, Wang, Hong-Li, Zhang, Hong-Yu, Zhang, Heng, Ma, Yan-Na, Yang, Shang-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168959/
https://www.ncbi.nlm.nih.gov/pubmed/25246966
http://dx.doi.org/10.3762/bjoc.10.215
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author Hu, Rong-Bin
Wang, Hong-Li
Zhang, Hong-Yu
Zhang, Heng
Ma, Yan-Na
Yang, Shang-dong
author_facet Hu, Rong-Bin
Wang, Hong-Li
Zhang, Hong-Yu
Zhang, Heng
Ma, Yan-Na
Yang, Shang-dong
author_sort Hu, Rong-Bin
collection PubMed
description Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R(2)-directed Pd-catalyzed C–H activation; the functionalized products are produced with good enantioselectivity.
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spelling pubmed-41689592014-09-22 P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands Hu, Rong-Bin Wang, Hong-Li Zhang, Hong-Yu Zhang, Heng Ma, Yan-Na Yang, Shang-dong Beilstein J Org Chem Letter Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R(2)-directed Pd-catalyzed C–H activation; the functionalized products are produced with good enantioselectivity. Beilstein-Institut 2014-09-02 /pmc/articles/PMC4168959/ /pubmed/25246966 http://dx.doi.org/10.3762/bjoc.10.215 Text en Copyright © 2014, Hu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Hu, Rong-Bin
Wang, Hong-Li
Zhang, Hong-Yu
Zhang, Heng
Ma, Yan-Na
Yang, Shang-dong
P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title_full P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title_fullStr P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title_full_unstemmed P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title_short P(O)R(2)-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
title_sort p(o)r(2)-directed pd-catalyzed c–h functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168959/
https://www.ncbi.nlm.nih.gov/pubmed/25246966
http://dx.doi.org/10.3762/bjoc.10.215
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