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Aggregation of biopharmaceuticals in human plasma and human serum: Implications for drug research and development

Analytical methods based on light microscopy, 90° light-scattering and surface plasmon resonance (SPR) allowed the characterization of aggregation that can occur when antibodies are mixed with human plasma. Light microscopy showed that aggregates formed when human plasma was mixed with 5% dextrose s...

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Detalles Bibliográficos
Autores principales: Arvinte, Tudor, Palais, Caroline, Green-Trexler, Erin, Gregory, Sonia, Mach, Henryk, Narasimhan, Chakravarthy, Shameem, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169040/
https://www.ncbi.nlm.nih.gov/pubmed/23571158
http://dx.doi.org/10.4161/mabs.24245