Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Blood lipid levels are heritable, treatable risk factors for cardiovascular disease. We systematically assessed genome-wide coding variation to identify novel lipid genes, fine-map known lipid loci, and evaluate whether low frequency variants with large effect exist. Using an exome array, we genotyp...

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Detalles Bibliográficos
Autores principales: Holmen, Oddgeir L., Zhang, He, Fan, Yanbo, Hovelson, Daniel H., Schmidt, Ellen M., Zhou, Wei, Guo, Yanhong, Zhang, Ji, Langhammer, Arnulf, Løchen, Maja-Lisa, Ganesh, Santhi K., Vatten, Lars, Skorpen, Frank, Dalen, Håvard, Zhang, Jifeng, Pennathur, Subramaniam, Chen, Jin, Platou, Carl, Mathiesen, Ellisiv B., Wilsgaard, Tom, Njølstad, Inger, Boehnke, Michael, Chen, Y. Eugene, Abecasis, Gonçalo R., Hveem, Kristian, Willer, Cristen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169222/
https://www.ncbi.nlm.nih.gov/pubmed/24633158
http://dx.doi.org/10.1038/ng.2926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169222/
https://www.ncbi.nlm.nih.gov/pubmed/24633158
http://dx.doi.org/10.1038/ng.2926

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