Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq

In this study, we improve on current autoantigen discovery approaches by creating a synthetic representation of the complete human proteome, the T7 “peptidome” phage display library (T7-Pep), and use it to profile the autoantibody repertoires of individual patients. We provide methods for 1) designi...

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Detalles Bibliográficos
Autores principales: Larman, H. Benjamin, Zhao, Zhenming, Laserson, Uri, Li, Mamie Z., Ciccia, Alberto, Gakidis, M. Angelica Martinez, Church, George M., Kesari, Santosh, LeProust, Emily M., Solimini, Nicole L., Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169279/
https://www.ncbi.nlm.nih.gov/pubmed/21602805
http://dx.doi.org/10.1038/nbt.1856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169279/
https://www.ncbi.nlm.nih.gov/pubmed/21602805
http://dx.doi.org/10.1038/nbt.1856

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