Doxycycline Indirectly Inhibits Proteolytic Activation of Tryptic Kallikrein-Related Peptidases and Activation of Cathelicidin

The increased abundance and activity of cathelicidin and kallikrein 5 (KLK5), a predominant trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of rosacea, a disorder treated by the use of low-dose doxycycline. Here we hypothesized that doxycycline ca...

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Detalles Bibliográficos
Autores principales: Kanada, Kimberly N., Nakatsuji, Teruaki, Gallo, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169281/
https://www.ncbi.nlm.nih.gov/pubmed/22336948
http://dx.doi.org/10.1038/jid.2012.14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169281/
https://www.ncbi.nlm.nih.gov/pubmed/22336948
http://dx.doi.org/10.1038/jid.2012.14

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