Prep1 (pKnox1) Regulates Mouse Embryonic HSC Cycling and Self-Renewal Affecting the Stat1-Sca1 IFN-Dependent Pathway

A hypomorphic Prep1 mutation results in embryonic lethality at late gestation with a pleiotropic embryonic phenotype that includes defects in all hematopoietic lineages. Reduced functionality of the hematopoietic stem cells (HSCs) compartment might be responsible for the hematopoietic phenotype obse...

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Detalles Bibliográficos
Autores principales: Modica, Livia, Iotti, Giorgio, D’Avola, Annalisa, Blasi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169458/
https://www.ncbi.nlm.nih.gov/pubmed/25233378
http://dx.doi.org/10.1371/journal.pone.0107916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169458/
https://www.ncbi.nlm.nih.gov/pubmed/25233378
http://dx.doi.org/10.1371/journal.pone.0107916

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