Ocular Localization and Transduction by Adenoviral Vectors Are Serotype-Dependent and Can Be Modified by Inclusion of RGD Fiber Modifications

PURPOSE: To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or subretinal administration. METHODS: Ocular transduction by adenoviral vector serotypes ± RGD was studied in the eyes of mice receiving a...

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Detalles Bibliográficos
Autores principales: Ueyama, Kazuhiro, Mori, Keisuke, Shoji, Takuhei, Omata, Hidekazu, Gehlbach, Peter L., Brough, Douglas E., Wei, Lisa L., Yoneya, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169476/
https://www.ncbi.nlm.nih.gov/pubmed/25232844
http://dx.doi.org/10.1371/journal.pone.0108071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169476/
https://www.ncbi.nlm.nih.gov/pubmed/25232844
http://dx.doi.org/10.1371/journal.pone.0108071

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