Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase

Fidelity of chromosome segregation is monitored by the spindle assembly checkpoint (SAC). Key components of the SAC include MAD1, MAD2, BUB1, BUB3, BUBR1, and MPS1. These proteins accumulate on kinetochores in early prometaphase but are displaced when chromosomes attach to microtubules and/or biorie...

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Detalles Bibliográficos
Autores principales: Kuijt, Timo E. F., Omerzu, Manja, Saurin, Adrian T., Kops, Geert J. P. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169584/
https://www.ncbi.nlm.nih.gov/pubmed/24695965
http://dx.doi.org/10.1007/s00412-014-0458-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169584/
https://www.ncbi.nlm.nih.gov/pubmed/24695965
http://dx.doi.org/10.1007/s00412-014-0458-9

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